International Journal of Human Nutrition and Functional Medicinewww.IntJHumNutrFunctMed.Org
2015 Final PDF
I also had some luck in having friends help me in
a critical juncture of my life. Without their help, I could
not have made all those works.
Of your scientific publications, which are your favorites,
or which do you think are most significant? And can you
give us a short summary of the significance of each?
Lee HK, Song JH, Shin CS, Park DJ, Park KS, Lee
KU, Koh CS. Decreased mitochondrial DNA content
in peripheral blood precedes the development of non-
insulin-dependent diabetes mellitus.
: This paper
showed for the first time that mtDNA depletion is the
‘cause’ of diabetes and closely associated with the
state of metabolic syndrome in a population-based
Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM,
Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K,
Nozawa Y, Lee HK, Tanaka M. Mitochondrial
haplogroup N9a confers resistance against type 2
diabetes in Asians.
Am J Hum Genet
: This paper established the fact that
genetic variation of mtDNA is a genetic factor of its
own. Understanding the genetic cause of chronic
disease could not be done by studying only genetic
variations of nuclear genome.
Lee HK, Shim EB. Extension of the mitochondria
dysfunction hypothesis of metabolic syndrome to
atherosclerosis with emphasis on the endocrine-
disrupting chemicals and biophysical laws.
: This paper shows that
mitochondria-based models or
predicts new ways of understanding
Park WH, Jun DW, Kim JT, Jeong JH, Park H, Chang
YS, Park KS, Lee HK, Pak YK. Novel cell-based
assay reveals associations of circulating serum AhR-
ligands with metabolic syndrome and mitochondrial
paper describes how one could measure serum AhR-
binding activity and mitochondrial inhibitor activity
with plain serum and how to interpret the significance.
Lee HK. Success of 2013-2020 World Health
Organization action plan to control non-
communicable diseases would require pollutants
J Diabetes Investig
This paper points out that current plan of the WHO to
control epidemic of diabetes and related chronic
diseases described in its book will not succeed if the
WHO does not consider the roles of EDCs in this
epidemic. The paper calls for a different approach.
Thank you for letting me ask you about my favorite
paper of yours. Your publication in late 2014 is really a
landmark paper in my opinion, because you extend
your work beyond the laboratory, and beyond the clinic
into the "real world" by noting that, in essence, if A
causes B then C must follow. In this case, A.
mitochondrial toxicity by pollutants appears to cause
or strongly contribute to B. diabetes, therefore C.
environmental pollution control must follow.
What must occur to effect a reduction in environmental
pollution? In this situation, the phrase "environmental
pollution" is misleading and vague, since we are really
talking about polluting and thus poisoning entire
patient populations. What needs to happen to change
I agree with you in that plan B should include
environmental pollution control. Also I agree with your
assessment that the phrase "environmental pollution" is
misleading and vague, since we are really talking about
polluting and thus poisoning entire world populations. We
are dealing with Black Death of the 21st century, which is
man-made. We have to set practical and achievable goals
based on sound science and methods. And persuade
people by showing understandable evidence. This is why
I am focusing on the measuring of EDCs and POPs and
trying to find links between exposure to them and the
development of diseases.
If you made a list of problems that you see in society
and the corresponding list of solutions, what would
How we can arrive at a social solution when billions of
people express their own views, all different and
Do you have anything else that you would like to share
with our readers?
The WHO and other leading health agencies are actively
incorporating knowledge on EDCs and POPs into their
policies. Mainstream biologists and medical specialists
are still not aware of the progress made in these specialties
and the importance for clinical care. The research needs
some time to get through, into clinical practice. I think
time is ripening to vindicate main features of functional
medicine, which is already being progressively
incorporated into mainstream medicine. I believe this new
medicine will be based on the mitochondrial
DNA/function unit, to accommodate evolution (genetics)
and thermodynamics—the two pillars of biology.
: Dr Lee's 2014 article (#5 above) has been archived
for easy access:www.ichnfm.org/library/Lee2014DmWHO.pdf